Preheat oven to 350 degrees F
Cut slices of bread into 3/4-inch cubes.
Add cubes of bread into a bowl and coat with olive oil. Stir gently to make sure all the bread is coated well.
Add seasonings into bowl: Italian seasoning, garlic powder, onion powder, and pepper. Gently stir to coat all bread cubes with seasoning.
Line a baking sheet with parchment paper and sprrad bread cubes evenly onto baking sheet.
Bake for 20 minutes, making sure to flip and turn croutons about halfway through cooking.
Take out of oven, let cool, and enjoy!